FBI trainee Clarice Starling ventures into a maximum-security asylum to pick the diseased brain of Hannibal Lecter, a psychiatrist turned homicidal cannibal. Starling needs clues to help her capture a serial killer. Unfortunately, her Faustian relationship with Lecter soon leads to his escape, and now two deranged killers are on the loose.
Two horror segments based on Edgar Allan Poe stories set in and around the city of Pittsburgh. "The Facts in the Case of M. Valdemar" concerns a cheating wife who is trying to scam her dying husband out of millions by having her doctor/hypnotist lover hypnotize the geezer into signing his dough over to her. The old man dies while under hypnosis and is stuck in the limbo between the here and the hereafter. The door to the physical world is opened and the undead attempt to enter it. "Black Cat" is the story of Rodd Usher, an alcoholic photographer/artist, who descends into madness after he kills a stray cat that his live-in girlfriend Annabelle brings home. One murder leads to another, and the complex cover-ups begin.